![]() 8 9 In light of this, rates of intestinal surgery and recurrence of strictures after surgery remain high and unchanged in FCD. 6 10 Although anti-inflammatory medical therapy is the standard of care, the evolution of strictures in FCD is thought to have a parallel pathogenesis that requires add-on antifibrotic treatment. Previous research indicates that >50% of patients with CD will develop intestinal strictures in their lifetimes. 5–8 Despite newer therapies now available or in development for IBD, none are approved for the treatment of fibrosis in IBD, hallmarking a critical unmet medical need for affected patients with fibrostenotic CD (FCD). 2–4 Stricturing is the result of ongoing chronic activation of myofibroblasts by inflammation in the GI lining. 1 Various phenotypes of CD have been characterised according to the Montreal classification based on age at diagnosis, gastrointestinal (GI) tract location, and behaviour of the disease course. Crohn’s disease (CD) is a type of inflammatory bowel disease (IBD) with a relapsing and remitting disease course.
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